🩸 Blood draw · Labcorp
Serum HRT Values Panel + Personalized Lab Results Education Report
HRT Optimization
Measures circulating hormone levels for women currently on hormone replacement therapy, providing data you can share with your prescribing provider.
Lab values are just one piece of the picture when it comes to HRT. Your prescribing provider will consider your results alongside your symptoms, history, and overall health when making any treatment decisions.
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Important: This panel measures circulating serum hormone levels only. It does not measure hormone metabolites or pathways. If you want a deeper picture of how your body is processing and metabolizing your HRT, consider pairing this panel with the In-Depth Hormone Analysis, Hormone Harmony Bundle, or Thrive in Balance Bundle.
This panel is a good fit if you are…
Currently taking HRT and want data to share with your prescribing provider
Experiencing persistent symptoms despite being on HRT
Working with a provider to optimize your HRT dose and delivery method
Hormone Replacement Therapy Considerations
Well suited for:
Oral estradiol (E2)
Estradiol (E2) patches
Estradiol pellets (E2)
Vaginal estradiol (E2)
Transdermal testosterone
Testosterone injections
Testosterone pellets
Limited insight (consider pairing with the DUTCH Complete):
Estradiol gels and creams
Serum estradiol levels can move up and down significantly within a few hours of application, meaning serum testing can easily underestimate actual levels. The DUTCH Complete is better suited for monitoring estradiol gels and creams as it measures hormone metabolites over a longer collection window rather than a single point in time.
Oral progesterone
Serum testing is not recommended for oral progesterone. If taken at bedtime, levels return to baseline within a few hours, making serum results unreliable depending on draw timing. Additionally, progesterone metabolites can cross-react with standard immunoassay tests, producing inaccurate results. The DUTCH Complete is the preferred method for oral progesterone as it measures progesterone metabolites in urine over a full day collection.
Vaginal progesterone
Serum values increase with vaginal progesterone dosing and likely reflect systemic exposure. However, vaginal progesterone benefits from a uterine first pass effect that delivers high concentrations directly to the uterus, which may be the primary therapeutic goal. Serum levels do not reflect uterine hormone concentrations, so clinical interpretation requires additional context beyond serum values alone.
Vaginal estradiol
Serum estradiol levels are generally low with vaginal estradiol use as systemic absorption is minimal at standard doses, which is intentional. Monitoring via serum is possible but symptom response is typically a more meaningful guide than serum values alone for this delivery method.
Symptoms you may be experiencing
Please never modify or discontinue your HRT without first consulting with your prescribing provider.
Markers Included
Estradiol (E2)
Progesterone
Total Testosterone
Free Testosterone
DHEA-S
SHBG
Estimated Turnaround Time
Requisition Delivery: Available in your Practice Better portal within 1–2 business days of your order being processed
Lab Processing: Approximately 5–10 business days after your blood draw at a Labcorp location
Lab Results Education Report: Approximately 3 business days of receiving your results
State Availability
This panel is available to residents of the contiguous United States, with the exception of New York, New Jersey, and Rhode Island due to state regulations.
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Every order is processed through Evexia Diagnostics’ Internal Physician Network (EIPN), a network of physicians who enable and facilitate the lab ordering process to meet state and federal requirements for direct-access testing. No action is needed on your end.
Not sure if this test is right for you?
Contact us at info@positywellness.com before placing your order.
$289one-time
Now Offering Buy Now, Pay Over Time Options
Save With a Bundle
The Serum HRT Values Panel is included in several of our curated bundles, a convenient way to combine multiple panels at a reduced price.
Not Sure Which Panel Is Right?
Take the free symptom quiz.
Answer a few questions about what you’re experiencing and get a panel recommendation based on your symptoms. Free, no email required.